Autoimmunity contributes to nociceptive sensitization in a mouse model of complex regional pain syndrome
WW Li, TZ Guo, X Shi, E Czirr, T Stan, P Sahbaie… - PAIN®, 2014 - Elsevier
Complex regional pain syndrome (CRPS) is a painful, disabling, chronic condition whose
etiology remains poorly understood. The recent suggestion that immunological mechanisms
may underlie CRPS provides an entirely novel framework in which to study the condition
and consider new approaches to treatment. Using a murine fracture/cast model of CRPS, we
studied the effects of B-cell depletion using anti-CD20 antibodies or by performing
experiments in genetically B-cell-deficient (μMT) mice. We observed that mice treated with …
etiology remains poorly understood. The recent suggestion that immunological mechanisms
may underlie CRPS provides an entirely novel framework in which to study the condition
and consider new approaches to treatment. Using a murine fracture/cast model of CRPS, we
studied the effects of B-cell depletion using anti-CD20 antibodies or by performing
experiments in genetically B-cell-deficient (μMT) mice. We observed that mice treated with …