[HTML][HTML] Gq pathway regulates proximal C-type lectin-like receptor-2 (CLEC-2) signaling in platelets

R Badolia, V Inamdar, BK Manne… - Journal of Biological …, 2017 - ASBMB
Platelets play a key role in the physiological hemostasis or pathological process of
thrombosis. Rhodocytin, an agonist of the C-type lectin-like receptor-2 (CLEC-2), elicits
powerful platelet activation signals in conjunction with Src family kinases (SFKs), spleen
tyrosine kinase (Syk), and phospholipase γ2 (PLCγ2). Previous reports have shown that
rhodocytin-induced platelet aggregation depends on secondary mediators such as
thromboxane A2 (TxA2) and ADP, which are agonists for G-protein-coupled receptors …