Harmful molecular mechanisms in sepsis

D Rittirsch, MA Flierl, PA Ward - Nature Reviews Immunology, 2008 - nature.com
D Rittirsch, MA Flierl, PA Ward
Nature Reviews Immunology, 2008nature.com
Sepsis and sepsis-associated multi-organ failure are major challenges for scientists and
clinicians and are a tremendous burden for health-care systems. Despite extensive basic
research and clinical studies, the pathophysiology of sepsis is still poorly understood. We
are now beginning to understand that sepsis is a heterogeneous, dynamic syndrome
caused by imbalances in the'inflammatory network'. In this Review, we highlight recent
insights into the molecular interactions that occur during sepsis and attempt to unravel the …
Abstract
Sepsis and sepsis-associated multi-organ failure are major challenges for scientists and clinicians and are a tremendous burden for health-care systems. Despite extensive basic research and clinical studies, the pathophysiology of sepsis is still poorly understood. We are now beginning to understand that sepsis is a heterogeneous, dynamic syndrome caused by imbalances in the 'inflammatory network'. In this Review, we highlight recent insights into the molecular interactions that occur during sepsis and attempt to unravel the nature of the dysregulated immune response during sepsis.
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