CXCR3-mediated opposite effects of CXCL10 and CXCL4 on TH1 or TH2 cytokine production
P Romagnani, L Maggi, B Mazzinghi, L Cosmi… - Journal of allergy and …, 2005 - Elsevier
BACKGROUND: Two variants of the CXCR3 receptor exist, one (CXCR3-A) reactive with
CXCL9, CXCL10, and CXCL11 and the other (CXCR3-B) also reactive with CXCL4. Both
variants are contemporarily expressed by human T cells. OBJECTIVE: We sought to
investigate the in vitro effects of CXCL10 and CXCL4 on the production of TH1 or TH2
cytokines. METHODS: The cytokine profile of antigen-specific human CD4+ T-cell lines
obtained in the absence or presence of CXCL10 or CXCL4 was evaluated by means of …
CXCL9, CXCL10, and CXCL11 and the other (CXCR3-B) also reactive with CXCL4. Both
variants are contemporarily expressed by human T cells. OBJECTIVE: We sought to
investigate the in vitro effects of CXCL10 and CXCL4 on the production of TH1 or TH2
cytokines. METHODS: The cytokine profile of antigen-specific human CD4+ T-cell lines
obtained in the absence or presence of CXCL10 or CXCL4 was evaluated by means of …