Major differences between human atopic dermatitis and murine models, as determined by using global transcriptomic profiling
Background Atopic dermatitis (AD) is caused by a complex interplay between immune and
barrier abnormalities. Murine models of AD are essential for preclinical assessments of new
treatments. Although many models have been used to simulate AD, their transcriptomic
profiles are not fully understood, and a comparison of these models with the human AD
transcriptomic fingerprint is lacking. Objective We sought to evaluate the transcriptomic
profiles of 6 common murine models and determine how they relate to human AD skin …
barrier abnormalities. Murine models of AD are essential for preclinical assessments of new
treatments. Although many models have been used to simulate AD, their transcriptomic
profiles are not fully understood, and a comparison of these models with the human AD
transcriptomic fingerprint is lacking. Objective We sought to evaluate the transcriptomic
profiles of 6 common murine models and determine how they relate to human AD skin …