Receptor-mediated antibody internalization is a key mechanism underlying several anti-
cancer antibody therapeutics. Delivering highly toxic drugs to cancer cells, as in the case of
antibody drug conjugates (ADCs), efficient removal of surface receptors from cancer cells
and changing the pharmacokinetics profile of the antibody drugs are some of key ways that
internalization impacts the therapeutic efficacy of the antibodies. Over the years, several
techniques have been used to study antibody internalization including radiolabels …