Adoptive immunotherapy for cancer: building on success

L Gattinoni, DJ Powell Jr, SA Rosenberg… - Nature Reviews …, 2006 - nature.com
Nature Reviews Immunology, 2006nature.com
Adoptive cell transfer after host preconditioning by lymphodepletion represents an important
advance in cancer immunotherapy. Here, we describe how a lymphopaenic environment
enables tumour-reactive T cells to destroy large burdens of metastatic tumour and how the
state of differentiation of the adoptively transferred T cells can affect the outcome of
treatment. We also discuss how the translation of these new findings might further improve
the efficacy of adoptive cell transfer through the use of vaccines, haematopoietic-stem-cell …
Abstract
Adoptive cell transfer after host preconditioning by lymphodepletion represents an important advance in cancer immunotherapy. Here, we describe how a lymphopaenic environment enables tumour-reactive T cells to destroy large burdens of metastatic tumour and how the state of differentiation of the adoptively transferred T cells can affect the outcome of treatment. We also discuss how the translation of these new findings might further improve the efficacy of adoptive cell transfer through the use of vaccines, haematopoietic-stem-cell transplantation, modified preconditioning regimens, and alternative methods for the generation and selection of the T cells to be transferred.
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