[PDF][PDF] Splicing of a divergent subclass of AT-AC introns requires the major spliceosomal snRNAs

Q Wu, AR Krainer - RNA-CAMBRIDGE-, 1997 - researchgate.net
AT-AC introns constitute a minor class of eukaryotic pre-mRNA introns, characterized by 5'-
AT and AC-3'boundaries, in contrast to the 5'-GT and AG-3'boundaries of the much more
prevalent conventional introns. In addition to the AT-AC borders, most known AT-AC introns
have highly conserved 5'splice site and branch site sequence elements of 7–8 nt. Intron 6 of
the nucleolar P120 gene and intron 2 of the SCN4A voltage-gated skeletal muscle sodium
channel are AT-AC introns that have been shown recently to be processed via a unique …