[HTML][HTML] Amphiregulin confers regulatory T cell suppressive function and tumor invasion via the EGFR/GSK-3β/Foxp3 axis
Previous studies mainly focused on the role of the epidermal growth factor receptor (EGFR)
in tumor cells, whereas the effects of the EGFR on immune responses has not been
determined. Our study shows that the EGFR signaling pathway play a role in the regulation
of regulatory T cells (Treg cells) in cancer patients. The EGF-like growth factor Amphiregulin
(AREG) protein was frequently up-regulated in a tissue microarray, which was associated
with worse overall survival. Additionally, in sera, tissue specimens, and effusions of lung or …
in tumor cells, whereas the effects of the EGFR on immune responses has not been
determined. Our study shows that the EGFR signaling pathway play a role in the regulation
of regulatory T cells (Treg cells) in cancer patients. The EGF-like growth factor Amphiregulin
(AREG) protein was frequently up-regulated in a tissue microarray, which was associated
with worse overall survival. Additionally, in sera, tissue specimens, and effusions of lung or …