[HTML][HTML] A versatile high-throughput assay to characterize antibody-mediated neutrophil phagocytosis

CB Karsten, N Mehta, SA Shin, TJ Diefenbach… - Journal of …, 2019 - Elsevier
Neutrophils, the most abundant white blood cell, play a critical role in anti-pathogen
immunity via phagocytic clearance, secretion of enzymes and immunomodulators, and the
release of extracellular traps. Neutrophils non-specifically sense infection through an array
of innate immune receptors and inflammatory sensors, but are also able to respond in a
pathogen/antigen-specific manner when leveraged by antibodies via Fc-receptors. Among
neutrophil functions, antibody-dependent neutrophil phagocytosis (ADNP) results in …