CD107a as a functional marker for the identification of natural killer cell activity

G Alter, JM Malenfant, M Altfeld - Journal of immunological methods, 2004 - Elsevier
Natural killer (NK) cells are a subset of lymphocytes that play a central role in the innate
immune response to tumors and infections. An important limitation in the field of NK research
is attributable to the deficit of assays available for the detection of the functional activity of NK
cells. Recently, lysosomal-associated membrane protein-1 (LAMP-1 or CD107a) has been
described as a marker of CD8+ T-cell degranulation following stimulation. Here we describe
CD107a as a marker of NK cell functional activity using multi-parameter flow cytometry …