Fibroblasts and myofibroblasts are believed to be the key effector cells in renal fibrogenesis
responsible for the synthesis and deposition of extracellular matrix components. In an
editorial written 15 yr ago, Gown claimed to have the mysteries of the fibroblast (partially)
unmasked (1). Unfortunately, 15 yr later many mysteries of the fibroblast and myofibroblasts
remain intact and we are only beginning to solve the riddle this cell poses. This manuscript
summarizes current understanding of the origin, phenotypic heterogeneity, and function of …