[HTML][HTML] Acute cellular rejection elicits distinct microRNA signatures in airway epithelium of lung transplant patients
Acute cellular rejection (ACR) is a common complication in lung transplantation and
associated with increased risk of chronic allograft dysfunction. MicroRNAs are critical
controllers of cellular transcription whose expression can be altered in disease states. The
purpose of this pilot study was to evaluate whether microRNA profiling of epithelial cells
obtained from airway brushings can distinguish lung transplant patients with ACR from those
without rejection. We studied 21 subjects (10 with ACR, 11 without ACR) and assessed the …
associated with increased risk of chronic allograft dysfunction. MicroRNAs are critical
controllers of cellular transcription whose expression can be altered in disease states. The
purpose of this pilot study was to evaluate whether microRNA profiling of epithelial cells
obtained from airway brushings can distinguish lung transplant patients with ACR from those
without rejection. We studied 21 subjects (10 with ACR, 11 without ACR) and assessed the …