Getting to the root of miRNA-mediated gene silencing
A Eulalio, E Huntzinger, E Izaurralde - Cell, 2008 - cell.com
A Eulalio, E Huntzinger, E Izaurralde
Cell, 2008•cell.comMicroRNAs are∼ 22 nucleotide-long RNAs that silence gene expression
posttranscriptionally by binding to the 3′ untranslated regions of target mRNAs. Although
much is known about their biogenesis and biological functions, the mechanisms allowing
miRNAs to silence gene expression in animal cells are still under debate. Here, we discuss
current models for miRNA-mediated gene silencing and formulate a hypothesis to reconcile
differences.
posttranscriptionally by binding to the 3′ untranslated regions of target mRNAs. Although
much is known about their biogenesis and biological functions, the mechanisms allowing
miRNAs to silence gene expression in animal cells are still under debate. Here, we discuss
current models for miRNA-mediated gene silencing and formulate a hypothesis to reconcile
differences.
MicroRNAs are ∼22 nucleotide-long RNAs that silence gene expression posttranscriptionally by binding to the 3′ untranslated regions of target mRNAs. Although much is known about their biogenesis and biological functions, the mechanisms allowing miRNAs to silence gene expression in animal cells are still under debate. Here, we discuss current models for miRNA-mediated gene silencing and formulate a hypothesis to reconcile differences.
cell.com