Myeloid-derived suppressor cells are proinflammatory and regulate collagen-induced arthritis through manipulating Th17 cell differentiation
H Zhang, S Wang, Y Huang, H Wang, J Zhao… - Clinical …, 2015 - Elsevier
Myeloid-derived suppressor cells (MDSC) and Th17 cells were found to expand in collagen-
induced arthritis (CIA) significantly. Two subsets of MDSC, polymorphonuclear (PMN) and
mononuclear (MO), were detected and their ratios varied during the development of CIA.
The depletion of MDSC in vivo resulted in suppression of T-cell proliferation and decreased
IL-17A and IL-1β production. The adoptive transfer of MDSC restored the severity of arthritis
and Th17 cell differentiation. The depletion of MDSCs on day 35 resulted in arthritis …
induced arthritis (CIA) significantly. Two subsets of MDSC, polymorphonuclear (PMN) and
mononuclear (MO), were detected and their ratios varied during the development of CIA.
The depletion of MDSC in vivo resulted in suppression of T-cell proliferation and decreased
IL-17A and IL-1β production. The adoptive transfer of MDSC restored the severity of arthritis
and Th17 cell differentiation. The depletion of MDSCs on day 35 resulted in arthritis …