Alpha-1-antitrypsin deficiency liver disease

D Patel, JH Teckman - Clinics in liver disease, 2018 - liver.theclinics.com
The liver is the primary site of synthesis of alpha-1-antitrypsin (AAT) protein, although it is
also made in enterocytes and some mononuclear white blood cells. 1 Large quantities of
AAT are secreted from the liver on a daily basis, second only to albumin as a mass of a
single serum protein. Almost all liver disease is associated with homozygosity for the Z
mutant of the AAT gene, although in some circumstances compound