Is autism caused by early hyperactivity of brain-derived neurotrophic factor?

SJ Tsai - Medical hypotheses, 2005 - Elsevier
Autism, a childhood-onset neurodevelopmental disorder, is characterized by disturbances in
socialization and language skills, as well as in perception. Several studies indicate the
importance of both genetic and environmental factors in the development of idiopathic
autism, but the underlying pathogenesis of this disorder is still unknown. Brain-derived
neurotrophic factor (BDNF) is important for normal neuronal development. Early BDNF
hyperactivity may play an etiological role in autism early in life. This hypothesis is supported …