The potassium chloride cotransporter KCC2 plays a major role in the maintenance of
transmembrane chloride potential in mature neurons; thus KCC2 activity is critical for
hyperpolarizing membrane currents generated upon the activation of γ-aminobutyric acid
type A and glycine (Gly) receptors that underlie fast synaptic inhibition in the adult central
nervous system. However, to date an understanding of the cellular mechanism that neurons
use to modulate the functional expression of KCC2 remains rudimentary. Using Escherichia …