Differentiating the pathologies of cerebral malaria by postmortem parasite counts
TE Taylor, WJ Fu, RA Carr, RO Whitten, JG Mueller… - Nature medicine, 2004 - nature.com
TE Taylor, WJ Fu, RA Carr, RO Whitten, JG Mueller, NG Fosiko, S Lewallen, NG Liomba…
Nature medicine, 2004•nature.comTo study the pathogenesis of fatal cerebral malaria, we conducted autopsies in 31 children
with this clinical diagnosis. We found that 23% of the children had actually died from other
causes. The remaining patients had parasites sequestered in cerebral capillaries, and 75%
of those had additional intra-and perivascular pathology. Retinopathy was the only clinical
sign distinguishing malarial from nonmalarial coma. These data have implications for
treating malaria patients, designing clinical trials and assessing malaria-specific disease …
with this clinical diagnosis. We found that 23% of the children had actually died from other
causes. The remaining patients had parasites sequestered in cerebral capillaries, and 75%
of those had additional intra-and perivascular pathology. Retinopathy was the only clinical
sign distinguishing malarial from nonmalarial coma. These data have implications for
treating malaria patients, designing clinical trials and assessing malaria-specific disease …
Abstract
To study the pathogenesis of fatal cerebral malaria, we conducted autopsies in 31 children with this clinical diagnosis. We found that 23% of the children had actually died from other causes. The remaining patients had parasites sequestered in cerebral capillaries, and 75% of those had additional intra- and perivascular pathology. Retinopathy was the only clinical sign distinguishing malarial from nonmalarial coma. These data have implications for treating malaria patients, designing clinical trials and assessing malaria-specific disease associations.
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