Sustained low levels of fibroblast growth factor-1 promote persistent microvascular network formation
S Uriel, EM Brey, HP Greisler - The American journal of surgery, 2006 - Elsevier
BACKGROUND: Therapeutic neovascularization using high growth factor concentrations
may lead to transient vessel formation and abnormal microvascular structure. The goal of
this study was to quantify temporal and concentration effects of fibroblast growth factor-1
(FGF-1) on the persistence and morphology of microvascular networks. METHODS:
Endothelial cells were incubated in suspension culture forming aggregates that were
embedded in fibrin glue (FG) and stimulated with varying concentrations of FGF-1 with of …
may lead to transient vessel formation and abnormal microvascular structure. The goal of
this study was to quantify temporal and concentration effects of fibroblast growth factor-1
(FGF-1) on the persistence and morphology of microvascular networks. METHODS:
Endothelial cells were incubated in suspension culture forming aggregates that were
embedded in fibrin glue (FG) and stimulated with varying concentrations of FGF-1 with of …