Cloning and expressions of three mammalian homologues of Drosophila slit suggest possible roles for Slit in the formation and maintenance of the nervous system
A Itoh, T Miyabayashi, M Ohno, S Sakano - Molecular brain research, 1998 - Elsevier
In Drosophila embryogenesis, the slit gene has been shown to play a critical role in CNS
midline formation. However, no slit homologues have been reported in vertebrates. Here, we
have identified mammalian homologues of the slit gene (human Slit-1, Slit-2, Slit-3, and rat
Slit-1). Each Slit gene encodes a putative secreted protein, which contains conserved
protein–protein interaction domains including leucine-rich repeats (LRR) and epidermal
growth factor (EGF)-like motifs, like that of the Drosophila protein. Northern blot analysis …
midline formation. However, no slit homologues have been reported in vertebrates. Here, we
have identified mammalian homologues of the slit gene (human Slit-1, Slit-2, Slit-3, and rat
Slit-1). Each Slit gene encodes a putative secreted protein, which contains conserved
protein–protein interaction domains including leucine-rich repeats (LRR) and epidermal
growth factor (EGF)-like motifs, like that of the Drosophila protein. Northern blot analysis …