[HTML][HTML] Yes-associated protein (YAP) mediates adaptive cardiac hypertrophy in response to pressure overload

J Byun, DP Del Re, P Zhai, S Ikeda, A Shirakabe… - Journal of Biological …, 2019 - ASBMB
Cardiovascular disease (CVD) remains the leading cause of death globally, and heart
failure is a major component of CVD-related morbidity and mortality. The development of
cardiac hypertrophy in response to hemodynamic overload is initially considered to be
beneficial; however, this adaptive response is limited and, in the presence of prolonged
stress, will transition to heart failure. Yes-associated protein (YAP), the central downstream
effector of the Hippo signaling pathway, regulates proliferation and survival in mammalian …