[HTML][HTML] CD44v6 coordinates tumor matrix-triggered motility and apoptosis resistance
T Jung, W Gross, M Zoeller - Journal of Biological Chemistry, 2011 - ASBMB
Tumor progression requires a crosstalk with the tumor surrounding, where the tumor matrix
plays an essential role. We recently reported that only the matrix delivered by a CD44v6-
competent (ASML wt), but not that of a CD44v6-deficient (ASML-CD44v kd) rat pancreatic
adenocarcinoma line supports metastasis formation. We here describe that this matrix
provides an important feedback toward the tumor cell and that CD44v6 accounts for
orchestrating signals received from the matrix. ASML wt cells contain more hyaluronan …
plays an essential role. We recently reported that only the matrix delivered by a CD44v6-
competent (ASML wt), but not that of a CD44v6-deficient (ASML-CD44v kd) rat pancreatic
adenocarcinoma line supports metastasis formation. We here describe that this matrix
provides an important feedback toward the tumor cell and that CD44v6 accounts for
orchestrating signals received from the matrix. ASML wt cells contain more hyaluronan …