Significance of CD44s and CD44v6 expression in pancreaticobiliary maljunction.
A Tsuchida, Y Nagakawa, K Kasuya… - Hepato …, 2011 - europepmc.org
A Tsuchida, Y Nagakawa, K Kasuya, T Matudo, B Kyo, Y Suzuki, T Aoki, E Sato, T Nagao…
Hepato-gastroenterology, 2011•europepmc.orgResults Among gallbladder lesions, cancerous lesions (dysplasia, cancer) had a higher
immunoreactivity with statistical significance for CD44s and CD44v6 compared to non-
cancerous lesions (normal, hyperplasia). In bile ducts as well, cancerous lesions had a
higher immunoreactivity for CD44s and CD44v6. In both gallbladders and bile ducts,
positive cases of CD44s and CD44v6 had a higher statistical significance of Ki-67 labeling
index in comparison with negative cases. Conclusions In biliary epithelium with PBM, CD44 …
immunoreactivity with statistical significance for CD44s and CD44v6 compared to non-
cancerous lesions (normal, hyperplasia). In bile ducts as well, cancerous lesions had a
higher immunoreactivity for CD44s and CD44v6. In both gallbladders and bile ducts,
positive cases of CD44s and CD44v6 had a higher statistical significance of Ki-67 labeling
index in comparison with negative cases. Conclusions In biliary epithelium with PBM, CD44 …
Results
Among gallbladder lesions, cancerous lesions (dysplasia, cancer) had a higher immunoreactivity with statistical significance for CD44s and CD44v6 compared to non-cancerous lesions (normal, hyperplasia). In bile ducts as well, cancerous lesions had a higher immunoreactivity for CD44s and CD44v6. In both gallbladders and bile ducts, positive cases of CD44s and CD44v6 had a higher statistical significance of Ki-67 labeling index in comparison with negative cases.
Conclusions
In biliary epithelium with PBM, CD44 was indicated to be strongly related to cancer progression via an increase of cellular proliferative potential.
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