[HTML][HTML] Liver ischemia and reperfusion injury: new insights into mechanisms of innate—adaptive immune-mediated tissue inflammation
Y Zhai, RW Busuttil, JW Kupiec-Weglinski - American Journal of …, 2011 - Elsevier
Ischemia and reperfusion injury (IRI) is a dynamic process that involves two distinctive yet
interrelated phases of ischemic organ damage and inflammation-mediated reperfusion
injury. Although multiple cellular and molecular pathways contribute and regulate
tissue/organ damage, integration of different players into a unified mechanism is warranted.
The crosstalk between innate and adaptive immune systems plays a significant role in the
pathogenesis of liver IRI. In this review, we focus on recent progress in the mechanism of …
interrelated phases of ischemic organ damage and inflammation-mediated reperfusion
injury. Although multiple cellular and molecular pathways contribute and regulate
tissue/organ damage, integration of different players into a unified mechanism is warranted.
The crosstalk between innate and adaptive immune systems plays a significant role in the
pathogenesis of liver IRI. In this review, we focus on recent progress in the mechanism of …