[PDF][PDF] Unbound amino acid concentrations in human blood plasmas

RH McMENAMY, CC Lund… - The Journal of clinical …, 1957 - Am Soc Clin Investig
RH McMENAMY, CC Lund, JL Oncley
The Journal of clinical investigation, 1957Am Soc Clin Investig
Studies of small molecules in plasma have indi-cated the importance of defining
concentrations in terms of both" unbound" and" total." For ex-ample, McLean and Hastings
(1) showed calcium was both bound and free in plasma, but that the free form was regulatory
in the body. Further, Davis (2) found it was the unbound concentra-tions of the sulfonamides
in the plasma which were active. In addition to these, cholesterol, fatty acids, bilirubin, estriol,
chloride and many others have been observed to bind with various affinities to the plasma …
Studies of small molecules in plasma have indi-cated the importance of defining concentrations in terms of both" unbound" and" total." For ex-ample, McLean and Hastings (1) showed calcium was both bound and free in plasma, but that the free form was regulatory in the body. Further, Davis (2) found it was the unbound concentra-tions of the sulfonamides in the plasma which were active. In addition to these, cholesterol, fatty acids, bilirubin, estriol, chloride and many others have been observed to bind with various affinities to the plasma proteins [see review by Surgenor
The Journal of Clinical Investigation