Streptococcal inhibitor of complement (SIC) modulates fibrinolysis and enhances bacterial survival within fibrin clots
Some strains of the bacterial pathogen Streptococcus pyogenes secrete protein SIC
(streptococcal inhibitor of complement), including strains of the clinically relevant M1
serotype. SIC neutralizes the effect of a number of antimicrobial proteins/peptides and
interferes with the function of the host complement system. Previous studies have shown that
some S. pyogenes proteins bind and modulate coagulation and fibrinolysis factors, raising
the possibility that SIC also may interfere with the activity of these factors. Here we show that …
(streptococcal inhibitor of complement), including strains of the clinically relevant M1
serotype. SIC neutralizes the effect of a number of antimicrobial proteins/peptides and
interferes with the function of the host complement system. Previous studies have shown that
some S. pyogenes proteins bind and modulate coagulation and fibrinolysis factors, raising
the possibility that SIC also may interfere with the activity of these factors. Here we show that …
