Immunization of human beings with group A hemolytic streptococci
LA Rantz, E Randall, HH Rantz - The American Journal of Medicine, 1949 - amjmed.com
LA Rantz, E Randall, HH Rantz
The American Journal of Medicine, 1949•amjmed.com1. Heat-killed group a hemolytic streptococci were administered subcutaneously to human
beings. 2.2. Type specific and other antibacterial antibodies developed only in those
subjects who received a very large amount of vaccine over a nine-week period. 3.3. Toxic
reactions were severe following the injection of small amounts of vaccine in certain persons.
Others accepted much larger amounts without difficulty. 4.4. Increased reactivity to the
injection of hemolytic streptococci developed in some subjects. This is believed to represent …
beings. 2.2. Type specific and other antibacterial antibodies developed only in those
subjects who received a very large amount of vaccine over a nine-week period. 3.3. Toxic
reactions were severe following the injection of small amounts of vaccine in certain persons.
Others accepted much larger amounts without difficulty. 4.4. Increased reactivity to the
injection of hemolytic streptococci developed in some subjects. This is believed to represent …
Abstract
- 1.1. Heat-killed group a hemolytic streptococci were administered subcutaneously to human beings.
- 2.2. Type specific and other antibacterial antibodies developed only in those subjects who received a very large amount of vaccine over a nine-week period.
- 3.3. Toxic reactions were severe following the injection of small amounts of vaccine in certain persons. Others accepted much larger amounts without difficulty.
- 4.4. Increased reactivity to the injection of hemolytic streptococci developed in some subjects. This is believed to represent artificially induced sensitivity of an immunologic type to the streptococcus or its products.
The authors are grateful to Warden Clinton Duffy, Dr. Leo Stanley and those prisoners of San Quentin prison whose voluntary cooperation made this work possible.
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