Species specificity of streptokinase
JA Marcum, DL Kline - Comparative Biochemistry and Physiology Part B …, 1983 - Elsevier
1. Streptokinase, a bacterial protein, forms a complex with human plasminogen which
results in a conformational change in the plasminogen molecule and the exposure of an
active center. 2. 2. The plasminogen-streptokinase complex is an activator of plasminogen
and is rapidly converted to a plasmin-streptokinase complex which, in the human, is also an
activator of plasminogen. 3. 3. Species differences have been found in the reaction of
streptokinase with plasminogen varying from no active complex formation at one extreme to …
results in a conformational change in the plasminogen molecule and the exposure of an
active center. 2. 2. The plasminogen-streptokinase complex is an activator of plasminogen
and is rapidly converted to a plasmin-streptokinase complex which, in the human, is also an
activator of plasminogen. 3. 3. Species differences have been found in the reaction of
streptokinase with plasminogen varying from no active complex formation at one extreme to …