Biological basis and pathological relevance of microvascular thrombosis

S Pfeiler, S Massberg, B Engelmann - Thrombosis research, 2014 - Elsevier
Microvascular thrombosis indicates a pathological occlusion of microvessels by fibrin-and/or
platelet-rich thrombi. It is observed during systemic infections, cancer, myocardial infarction,
stroke, neurodegenerative diseases and in thrombotic microangiopathies. Microvessel
thrombosis can cause greatly differing symptoms that range from limited changes in plasma
coagulation markers to severe multi-organ failure. Because microvessel thrombi are difficult
to detect and often occur only transiently, their importance for disease development and host …