The emerging role of neutrophil extracellular traps in respiratory disease

SH Twaddell, KJ Baines, C Grainge, PG Gibson - Chest, 2019 - Elsevier
Neutrophil extracellular traps (NETs) are extrusions of intracellular DNA and attached
granular material that enable bacterial killing. NETs are increasingly recognized for their role
in the pathogenesis of respiratory disease. NETs are composed of a complex mix of
intracellularly derived material that neutrophils organize within the cytoplasm and then expel
in a nondirected manner in the vicinity of invading organisms. Combined, these trap and
destroy multiple genera of microbes including bacteria, fungi, viruses, and protozoans …