Matrix metalloproteinases as modulators of inflammation and innate immunity
WC Parks, CL Wilson, YS López-Boado - Nature Reviews Immunology, 2004 - nature.com
WC Parks, CL Wilson, YS López-Boado
Nature Reviews Immunology, 2004•nature.comAs their name implies, matrix metalloproteinases are thought to be responsible for the
turnover and degradation of the extracellular matrix. However, matrix degradation is neither
the sole nor the main function of these proteinases. Indeed, as we discuss here, recent
findings indicate that matrix metalloproteinases act on pro-inflammatory cytokines,
chemokines and other proteins to regulate varied aspects of inflammation and immunity.
turnover and degradation of the extracellular matrix. However, matrix degradation is neither
the sole nor the main function of these proteinases. Indeed, as we discuss here, recent
findings indicate that matrix metalloproteinases act on pro-inflammatory cytokines,
chemokines and other proteins to regulate varied aspects of inflammation and immunity.
Abstract
As their name implies, matrix metalloproteinases are thought to be responsible for the turnover and degradation of the extracellular matrix. However, matrix degradation is neither the sole nor the main function of these proteinases. Indeed, as we discuss here, recent findings indicate that matrix metalloproteinases act on pro-inflammatory cytokines, chemokines and other proteins to regulate varied aspects of inflammation and immunity.
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