[HTML][HTML] Immunopolarization of CD4+ and CD8+ T cells to type-1–like is associated with melanocyte loss in human vitiligo
A Wańkowicz-Kalińska, RM van den Wijngaard… - Laboratory …, 2003 - Elsevier
Vitiligo is an autoimmune condition characterized by loss of epidermal melanocytes. High
frequencies of melanocyte-reactive cytotoxic T cells in the peripheral blood of vitiligo
patients and the observed correlation between perilesional T-cell infiltration and melanocyte
loss in situ suggest the important role of cellular autoimmunity in the pathogenesis of this
disease. We isolated T cells from both perilesional and nonlesional skin biopsies obtained
from five vitiligo patients, then cloned and analyzed their profile of cytokine production after …
frequencies of melanocyte-reactive cytotoxic T cells in the peripheral blood of vitiligo
patients and the observed correlation between perilesional T-cell infiltration and melanocyte
loss in situ suggest the important role of cellular autoimmunity in the pathogenesis of this
disease. We isolated T cells from both perilesional and nonlesional skin biopsies obtained
from five vitiligo patients, then cloned and analyzed their profile of cytokine production after …