A novel myelin-associated glycoprotein defined by a mouse monoclonal antibody
C Linnington, M Webb, PL Woodhams - Journal of neuroimmunology, 1984 - Elsevier
A novel myelin antigen has been defined by a mouse monoclonal antibody (8-18C5) raised
against rat cerebellar glycoproteins. By immunohistochemistry, the antigen was detected in
white matter tracts of the central nervous system, but was absent from peripheral myelin.
Western blotting followed by immunistaining revealed that the antigen was a glycoprotein of
Mr 51 000 daltons which was degraded on storage to cross-reacting products of 20–26 000
daltons. Antigen was detected in central but not peripheral nervous system samples …
against rat cerebellar glycoproteins. By immunohistochemistry, the antigen was detected in
white matter tracts of the central nervous system, but was absent from peripheral myelin.
Western blotting followed by immunistaining revealed that the antigen was a glycoprotein of
Mr 51 000 daltons which was degraded on storage to cross-reacting products of 20–26 000
daltons. Antigen was detected in central but not peripheral nervous system samples …