B cell follicle-like structures in multiple sclerosis—with focus on the role of B cell activating factor
M Haugen, JL Frederiksen, M Degn - Journal of Neuroimmunology, 2014 - Elsevier
B lymphocytes play an important role in the pathogenesis of multiple sclerosis (MS). Follicle-
like structures (FLS) have recently been found in the subarachnoid space in the
leptomeninges in some patients with secondary progressive MS (SPMS). They contain
proliferating B lymphocytes, plasma cells, helper T lymphocytes and a network of follicular
dendritic cells. FLS have been shown to correlate with increased cortical demyelination,
neuronal loss, meningeal infiltration and central nervous system inflammation, as well as …
like structures (FLS) have recently been found in the subarachnoid space in the
leptomeninges in some patients with secondary progressive MS (SPMS). They contain
proliferating B lymphocytes, plasma cells, helper T lymphocytes and a network of follicular
dendritic cells. FLS have been shown to correlate with increased cortical demyelination,
neuronal loss, meningeal infiltration and central nervous system inflammation, as well as …