Post-natal paucity of regulatory T cells and control of NK cell activation in experimental biliary atresia
AG Miethke, V Saxena, P Shivakumar, GE Sabla… - Journal of …, 2010 - Elsevier
BACKGROUND & AIMS: Although recent studies have identified important roles for T and
NK cells in the pathogenesis of biliary atresia (BA), the mechanisms by which susceptibility
to bile duct injury is restricted to the neonatal period are unknown. METHODS: We
characterised hepatic regulatory T cells (Tregs) by flow cytometry in two groups of neonatal
mice challenged with rhesus rotavirus (RRV) at day 7 (no ductal injury) or day 1 of life
(resulting in BA), determined the functional interaction with effector cells in co-culture …
NK cells in the pathogenesis of biliary atresia (BA), the mechanisms by which susceptibility
to bile duct injury is restricted to the neonatal period are unknown. METHODS: We
characterised hepatic regulatory T cells (Tregs) by flow cytometry in two groups of neonatal
mice challenged with rhesus rotavirus (RRV) at day 7 (no ductal injury) or day 1 of life
(resulting in BA), determined the functional interaction with effector cells in co-culture …