[HTML][HTML] Kidney allograft fibrosis and atrophy early after living donor transplantation
FG Cosio, JP Grande, TS Larson, JM Gloor… - American journal of …, 2005 - Elsevier
Kidney allograft failure is most often caused by chronic allograft nephropathy, a process of
interstitial fibrosis (GIF) and tubular atrophy (TA). We assessed the pathology of living donor
(LD) grafts compared to deceased donor (DD). Included are 321 recipients (245 LD; 76 DD)
with protocol biopsies the first 2 years of transplant. In LD, GIF was present in 7%, 31%, 61%
and 71% of grafts at 0, 4, 12 and 24 months. TA progressed in parallel to GIF. Compared to
LD, more DD grafts had GIF at time (29%, p= 0.002); thereafter the incidence of GIF was …
interstitial fibrosis (GIF) and tubular atrophy (TA). We assessed the pathology of living donor
(LD) grafts compared to deceased donor (DD). Included are 321 recipients (245 LD; 76 DD)
with protocol biopsies the first 2 years of transplant. In LD, GIF was present in 7%, 31%, 61%
and 71% of grafts at 0, 4, 12 and 24 months. TA progressed in parallel to GIF. Compared to
LD, more DD grafts had GIF at time (29%, p= 0.002); thereafter the incidence of GIF was …