Influence of age at virologic control on peripheral blood human immunodeficiency virus reservoir size and serostatus in perinatally infected adolescents
Importance Combination antiretroviral therapy initiated within several weeks of human
immunodeficiency virus (HIV) infection in adults limits proviral reservoirs that preclude HIV
cure. Biomarkers of restricted proviral reservoirs may aid in the monitoring of HIV remission
or cure. Objectives To quantify peripheral blood proviral reservoir size in perinatally HIV-
infected (PHIV+) adolescents and to identify correlates of limited proviral reservoirs. Design,
Setting, and Participants A cross-sectional study including 144 PHIV+ youths (median age …
immunodeficiency virus (HIV) infection in adults limits proviral reservoirs that preclude HIV
cure. Biomarkers of restricted proviral reservoirs may aid in the monitoring of HIV remission
or cure. Objectives To quantify peripheral blood proviral reservoir size in perinatally HIV-
infected (PHIV+) adolescents and to identify correlates of limited proviral reservoirs. Design,
Setting, and Participants A cross-sectional study including 144 PHIV+ youths (median age …