[HTML][HTML] Tumor necrosis factor-α inhibits expression of CTP: phosphocholine cytidylyltransferase
RK Mallampalli, AJ Ryan, RG Salome… - Journal of Biological …, 2000 - ASBMB
We investigated the effects of tumor necrosis factor α (TNFα), a key cytokine involved in
inflammatory lung disease, on phosphatidylcholine (PtdCho) biosynthesis in a murine
alveolar type II epithelial cell line (MLE-12). TNFα significantly inhibited [3 H] choline
incorporation into PtdCho after 24 h of exposure. TNFα reduced the activity of CTP:
phosphocholine cytidylyltransferase (CCT), the rate-regulatory enzyme within the CDP-
choline pathway, by 40% compared with control, but it did not alter activities of choline …
inflammatory lung disease, on phosphatidylcholine (PtdCho) biosynthesis in a murine
alveolar type II epithelial cell line (MLE-12). TNFα significantly inhibited [3 H] choline
incorporation into PtdCho after 24 h of exposure. TNFα reduced the activity of CTP:
phosphocholine cytidylyltransferase (CCT), the rate-regulatory enzyme within the CDP-
choline pathway, by 40% compared with control, but it did not alter activities of choline …