Long-term tolerance to allogeneic thymus transplants in complete DiGeorge anomaly
IK Chinn, BH Devlin, YJ Li, ML Markert - Clinical Immunology, 2008 - Elsevier
Thymus transplantation in subjects with complete DiGeorge anomaly using postnatal
allogeneic HLA-nonmatched cultured thymus tissue provides immunoreconstitution.
Tolerance of the newly developed T cells toward the donor thymus has not previously been
studied. Mixed lymphocyte cultures were used to test 12 thymus transplant recipients for
long-term tolerance toward their thymus allografts. Two subjects tested for responses toward
thymus donor peripheral blood mononuclear cells showed significantly less reactivity toward …
allogeneic HLA-nonmatched cultured thymus tissue provides immunoreconstitution.
Tolerance of the newly developed T cells toward the donor thymus has not previously been
studied. Mixed lymphocyte cultures were used to test 12 thymus transplant recipients for
long-term tolerance toward their thymus allografts. Two subjects tested for responses toward
thymus donor peripheral blood mononuclear cells showed significantly less reactivity toward …