[HTML][HTML] Signaling via macrophage G2A enhances efferocytosis of dying neutrophils by augmentation of Rac activity
SC Frasch, RF Fernandez-Boyanapalli, KZ Berry… - Journal of Biological …, 2011 - ASBMB
Phosphatidylserine (PS) and oxidized PS species have been identified as key ligands on
apoptotic cells important for their recognition and removal (efferocytosis) by phagocytes, a
requisite step for resolution of inflammation. We have recently demonstrated that
lysophosphatidylserine (lyso-PS) generated and retained on neutrophils following short term
activation of the NADPH oxidase in vitro and in vivo enhanced their clearance via signaling
through the macrophage G-protein-coupled receptor G2A. Here, we investigated the …
apoptotic cells important for their recognition and removal (efferocytosis) by phagocytes, a
requisite step for resolution of inflammation. We have recently demonstrated that
lysophosphatidylserine (lyso-PS) generated and retained on neutrophils following short term
activation of the NADPH oxidase in vitro and in vivo enhanced their clearance via signaling
through the macrophage G-protein-coupled receptor G2A. Here, we investigated the …