[HTML][HTML] 25-Hydroxycholesterol activates the expression of cholesterol 25-hydroxylase in an LXR-dependent mechanism [S]
Cholesterol 25-hydroxylase (CH25H) catalyzes the production of 25-hydroxycholesterol (25-
HC), an oxysterol that can play an important role in different biological processes. However,
the mechanisms regulating CH25H expression have not been fully elucidated. In this study,
we determined that CH25H is highly expressed in mouse liver and peritoneal macrophages.
We identified several liver X receptor (LXR) response elements (LXREs) in the human
CH25H promoter. In HepG2 cells, activation of LXR by 25-HC or other oxysterols and …
HC), an oxysterol that can play an important role in different biological processes. However,
the mechanisms regulating CH25H expression have not been fully elucidated. In this study,
we determined that CH25H is highly expressed in mouse liver and peritoneal macrophages.
We identified several liver X receptor (LXR) response elements (LXREs) in the human
CH25H promoter. In HepG2 cells, activation of LXR by 25-HC or other oxysterols and …