[HTML][HTML] Absence of Nceh1 augments 25-hydroxycholesterol-induced ER stress and apoptosis in macrophages [S]
M Sekiya, D Yamamuro, T Ohshiro, A Honda… - Journal of lipid …, 2014 - ASBMB
An excess of cholesterol and/or oxysterols induces apoptosis in macrophages, contributing
to the development of advanced atherosclerotic lesions. In foam cells, these sterols are
stored in esterified forms, which are hydrolyzed by two enzymes: neutral cholesterol ester
hydrolase 1 (Nceh1) and hormone-sensitive lipase (Lipe). A deficiency in either enzyme
leads to accelerated growth of atherosclerotic lesions in mice. However, it is poorly
understood how the esterification and hydrolysis of sterols are linked to apoptosis …
to the development of advanced atherosclerotic lesions. In foam cells, these sterols are
stored in esterified forms, which are hydrolyzed by two enzymes: neutral cholesterol ester
hydrolase 1 (Nceh1) and hormone-sensitive lipase (Lipe). A deficiency in either enzyme
leads to accelerated growth of atherosclerotic lesions in mice. However, it is poorly
understood how the esterification and hydrolysis of sterols are linked to apoptosis …