[HTML][HTML] MicroRNA-33 regulates the innate immune response via ATP binding cassette transporter-mediated remodeling of membrane microdomains

L Lai, KM Azzam, WC Lin, P Rai, JM Lowe… - Journal of Biological …, 2016 - ASBMB
MicroRNAs (miRNAs) are short non-coding RNAs that regulate gene expression by
promoting degradation and/or repressing translation of specific target mRNAs. Several
miRNAs have been identified that regulate the amplitude of the innate immune response by
directly targeting Toll-like receptor (TLR) pathway members and/or cytokines. miR-33a and
miR-33b (the latter present in primates but absent in rodents and lower species) are located
in introns of the sterol regulatory element-binding protein (SREBP)-encoding genes and …