On the formation and possible biological role of 25-hydroxycholesterol
U Diczfalusy - Biochimie, 2013 - Elsevier
The oxysterol 25-hydroxycholesterol is a widely used compound displaying an array of
pharmacological actions in in vitro systems and cell based experimental systems. In spite of
the frequent use of this compound over the last few decades and a large number of studies
in vitro and in vivo, its mechanism of formation in vivo is still not well understood. Cholesterol
autoxidation does not seem to be an important contributor to in vivo formation of 25-
hydroxycholesterol. A number of different cytochrome P450 enzymes such as CYP27A1 and …
pharmacological actions in in vitro systems and cell based experimental systems. In spite of
the frequent use of this compound over the last few decades and a large number of studies
in vitro and in vivo, its mechanism of formation in vivo is still not well understood. Cholesterol
autoxidation does not seem to be an important contributor to in vivo formation of 25-
hydroxycholesterol. A number of different cytochrome P450 enzymes such as CYP27A1 and …
