IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors
YJ Liu - Annu. Rev. Immunol., 2005 - annualreviews.org
▪ Abstract Type 1 interferon-(α, β, ω)-producing cells (IPCs), also known as plasmacytoid
dendritic cell precursors (pDCs), represent 0.2%–0.8% of peripheral blood mononuclear
cells in both humans and mice. IPCs display plasma cell morphology, selectively express
Toll-like receptor (TLR)-7 and TLR9, and are specialized in rapidly secreting massive
amounts of type 1 interferon following viral stimulation. IPCs can promote the function of
natural killer cells, B cells, T cells, and myeloid DCs through type 1 interferons during an …
dendritic cell precursors (pDCs), represent 0.2%–0.8% of peripheral blood mononuclear
cells in both humans and mice. IPCs display plasma cell morphology, selectively express
Toll-like receptor (TLR)-7 and TLR9, and are specialized in rapidly secreting massive
amounts of type 1 interferon following viral stimulation. IPCs can promote the function of
natural killer cells, B cells, T cells, and myeloid DCs through type 1 interferons during an …
