[PDF][PDF] Bursting enables GRP neurons to engage spinal itch circuits
Neuron, 2019•cell.com
Bursting Enables GRP Neurons to Engage Spinal Itch Circuits Page 1 expands our
understanding of goaldirected learning mechanisms. REFERENCES Albin, RL, Young, AB, and
Penney, JB (1989). The functional anatomy of basal ganglia disorders. Trends Neurosci. 12,
366–375. Brown, MT, Tan, KR, O’Connor, EC, Nikonenko, I., Muller, D., and Lüscher, C. (2012).
Ventral tegmental area GABA projections pause accumbal cholinergic interneurons to enhance
associative learning. Nature 492, 452–456. Gritton, HJ, Howe, WM, Romano, MF …
understanding of goaldirected learning mechanisms. REFERENCES Albin, RL, Young, AB, and
Penney, JB (1989). The functional anatomy of basal ganglia disorders. Trends Neurosci. 12,
366–375. Brown, MT, Tan, KR, O’Connor, EC, Nikonenko, I., Muller, D., and Lüscher, C. (2012).
Ventral tegmental area GABA projections pause accumbal cholinergic interneurons to enhance
associative learning. Nature 492, 452–456. Gritton, HJ, Howe, WM, Romano, MF …
In this issue of Neuron, Pagani et al. (2019) find that itch signaling occurs only when GRP neurons fire action potentials in bursts. This enables GRP release and the activation of GRPR neurons, which help carry the itch signal to the brain.
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