[HTML][HTML] The protease-activated receptor-2-specific agonists 2-aminothiazol-4-yl-LIGRL-NH2 and 6-aminonicotinyl-LIGRL-NH2 stimulate multiple signaling pathways …
Protease-activated receptor-2 (PAR 2) is one of four protease-activated G-protein-coupled
receptors. PAR 2 is expressed on multiple cell types where it contributes to cellular
responses to endogenous and exogenous proteases. Proteolytic cleavage of PAR 2 reveals
a tethered ligand that activates PAR 2 and two major downstream signaling pathways:
mitogen-activated protein kinase (MAPK) and intracellular Ca 2+ signaling. Peptides or
peptidomimetics can mimic binding of the tethered ligand to stimulate signaling without the …
receptors. PAR 2 is expressed on multiple cell types where it contributes to cellular
responses to endogenous and exogenous proteases. Proteolytic cleavage of PAR 2 reveals
a tethered ligand that activates PAR 2 and two major downstream signaling pathways:
mitogen-activated protein kinase (MAPK) and intracellular Ca 2+ signaling. Peptides or
peptidomimetics can mimic binding of the tethered ligand to stimulate signaling without the …
