Tryptase-PAR2 axis in experimental autoimmune prostatitis, a model for chronic pelvic pain syndrome
K Roman, JD Done, AJ Schaeffer, SF Murphy… - PAIN®, 2014 - Elsevier
Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) affects up to 15% of the male
population and is characterized by pelvic pain. Mast cells are implicated in the murine
experimental autoimmune prostatitis (EAP) model as key to chronic pelvic pain
development. The mast cell mediator tryptase-β and its cognate receptor protease-activated
receptor 2 (PAR2) are involved in mediating pain in other visceral disease models. Prostatic
secretions and urines from CP/CPPS patients were examined for the presence of mast cell …
population and is characterized by pelvic pain. Mast cells are implicated in the murine
experimental autoimmune prostatitis (EAP) model as key to chronic pelvic pain
development. The mast cell mediator tryptase-β and its cognate receptor protease-activated
receptor 2 (PAR2) are involved in mediating pain in other visceral disease models. Prostatic
secretions and urines from CP/CPPS patients were examined for the presence of mast cell …