Dysregulated CD4+ T cells from SLE-susceptible mice are sufficient to accelerate atherosclerosis in LDLr−/− mice
AJ Wilhelm, JP Rhoads, NS Wade, AS Major - Annals of the rheumatic …, 2015 - Elsevier
Objective Accelerated atherosclerosis is a major source of morbidity in systemic lupus
erythematosus (SLE). However, the cause of SLE-accelerated atherosclerosis remains
unclear. Methods CD4+ T cells from C57/Bl/6 (B6) or SLE-susceptible B6. Sle1. 2.3 (B6.
SLE) mice were transferred into LDLr−/−, Rag−/− mice. T cells were examined for cytokine
production and expression of interleukin-10 receptor (IL-10R) and functional markers. T cells
were isolated based on FoxP3 GFP expression and transferred to LDLr−/−, Rag−/− mice to …
erythematosus (SLE). However, the cause of SLE-accelerated atherosclerosis remains
unclear. Methods CD4+ T cells from C57/Bl/6 (B6) or SLE-susceptible B6. Sle1. 2.3 (B6.
SLE) mice were transferred into LDLr−/−, Rag−/− mice. T cells were examined for cytokine
production and expression of interleukin-10 receptor (IL-10R) and functional markers. T cells
were isolated based on FoxP3 GFP expression and transferred to LDLr−/−, Rag−/− mice to …
